Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

4.9K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
4.9K
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.3K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brief Investigation: Investigating the role of phosphodiesterase Pde2 in coordinating the yeast Environmental Stress Response.

bioRxiv : the preprint server for biology·2026
Same author

Twenty-Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology.

Yeast (Chichester, England)·2026
Same author

Neighborhood-Level Disadvantage Impacts Multiple Measures of Brain Health: An Imaging Epidemiology Study.

bioRxiv : the preprint server for biology·2026
Same author

The importance of regulated resource reallocation during dynamic environmental shifts in yeast.

The EMBO journal·2026
Same author

Imaging in the fast lane: Challenges and opportunities for expanding access to MRI.

AJNR. American journal of neuroradiology·2026
Same author

Smoking Behavior Is Associated With an Altered Immune Landscape in Prostate Cancer: Implications for Patient Outcomes.

The Prostate·2026

Related Experiment Video

Updated: May 30, 2025

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

10.3K

Intrinsic Gene Expression Correlates of the Biophysically Modeled Diffusion Magnetic Resonance Imaging Signal.

Ajay P Singh1, Michael Fromandi2, Daniel Pimentel-Alarcón3

  • 1Graduate Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin.

Biological Psychiatry Global Open Science
|January 29, 2025
PubMed
Summary

This study reveals that diffusion Magnetic Resonance Imaging (dMRI) texture analysis, specifically neurite orientation dispersion and density imaging (NODDI), correlates with gene expression in autism spectrum disorder models. This finding links imaging to molecular neurobiology in autism research.

Keywords:
ASDDiffusion MRIImaging transcriptomicsImaging-gene correlatesNODDIQuantitative neuroimaging

More Related Videos

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.5K
Diffusion Imaging in the Rat Cervical Spinal Cord
10:46

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

11.6K

Related Experiment Videos

Last Updated: May 30, 2025

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

10.3K
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.5K
Diffusion Imaging in the Rat Cervical Spinal Cord
10:46

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

11.6K

Area of Science:

  • Neuroimaging
  • Molecular Neurobiology
  • Genetics

Background:

  • Magnetic Resonance Imaging (MRI) offers structural and functional insights into neurological disorders but limited molecular detail.
  • Autism Spectrum Disorder (ASD) research seeks to understand its complex neurobiological underpinnings.
  • Diffusion MRI techniques like NODDI provide microstructural information about brain tissue.

Purpose of the Study:

  • To investigate the relationship between diffusion MRI signals and gene expression in rat models of ASD.
  • To determine if specific NODDI indices correlate with intracellular and extracellular gene expression.
  • To explore the potential of diffusion MRI in probing neurobiological mechanisms relevant to ASD.

Main Methods:

  • Utilized rat genetic models of autism spectrum disorder.
  • Applied image texture-processed neurite orientation dispersion and density imaging (NODDI) diffusion MRI.
  • Correlated NODDI-derived signals (neurite density index, orientation dispersion index) with gene expression data.

Main Results:

  • Demonstrated an intrinsic relationship between texture-processed NODDI diffusion MRI and gene expression.
  • Found that neurite density index correlates with intracellular gene expression.
  • Showed that orientation dispersion index correlates with extracellular gene expression, including genes relevant to ASD etiopathogenesis.

Conclusions:

  • Diffusion MRI signals possess fundamental relationships with gene expression.
  • Texture-processed NODDI dMRI can potentially probe causal neurobiological mechanisms in neuroimaging phenotypes of ASD.
  • This approach offers a novel link between in vivo imaging and molecular pathology in autism research.