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Summary

This case report highlights a rare forehead presentation of primary cutaneous anaplastic large cell lymphoma (ALCL), a CD30-positive T-cell lymphoma. Early diagnosis and advanced therapies are crucial for managing this uncommon skin cancer.

Keywords:
cutaneous t cell lymphomadefinitive treatmentonco dermatologyr-chop therapysurgical dermatology

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Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Primary cutaneous anaplastic large cell lymphoma (ALCL) is a rare CD30-positive T-cell neoplasm.
  • Cutaneous ALCL infrequently presents on the forehead, often mimicking benign conditions.

Observation:

  • A 68-year-old male presented with a forehead ulcerative lesion initially misdiagnosed.
  • Fine needle aspiration indicated a lymphoproliferative disorder.
  • Biopsy and immunohistochemistry confirmed ALK-negative primary cutaneous ALCL.

Findings:

  • The patient achieved a complete response following standardized chemotherapy.
  • This case emphasizes ALCL as a differential diagnosis for persistent facial ulcerative lesions.

Implications:

  • Early diagnosis of cutaneous ALCL is vital for effective treatment.
  • Multidisciplinary management and novel therapies like Brentuximab Vedotin + CHP improve patient outcomes.
  • Consideration of rare presentations of cutaneous lymphoma is essential in clinical practice.