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Hyperbaric Oxygen Therapy for Management of Complex Regional Pain Syndrome
Joon Cha1, Gerardo Bosco2, Richard E Moon3
1Morsani College of Medicine.
The Clinical Journal of Pain
|January 29, 2025
Summary
Hyperbaric oxygen therapy (HBOT) shows significant efficacy in treating Complex Regional Pain Syndrome (CRPS), offering symptom relief and functional improvement for both sympathetically maintained pain (SMP) and sympathetically independent pain (SIP) subtypes.
Area of Science:
- Pain Management
- Neurology
- Oxygen Therapy
Background:
- Complex Regional Pain Syndrome (CRPS) is a debilitating condition with persistent pain and inflammatory symptoms.
- Current treatment options for CRPS have limitations, necessitating exploration of novel therapeutic approaches.
Purpose of the Study:
- To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) in managing Complex Regional Pain Syndrome (CRPS).
- To analyze HBOT's effectiveness across different CRPS subtypes, including sympathetically maintained pain (SMP) and sympathetically independent pain (SIP).
Main Methods:
- A comprehensive literature search was performed in PubMed Clinical Queries for studies on CRPS and HBOT.
- Included publication types: RCTs, retrospective observational studies, comparative studies, case series, and case reports (1994-2024).
- Patients were classified into SMP, SIP, or indeterminate groups based on clinical history.
Main Results:
- Thirteen studies involving 280 participants were reviewed.
- Significant symptom relief and functional improvements were observed in both SMP and SIP subtypes following HBOT.
- HBOT protocols varied, typically involving 2.4 ATA for 90 minutes over 3-63 sessions.
Conclusions:
- HBOT demonstrates broad efficacy in managing CRPS, irrespective of subtype or disease duration.
- HBOT's anti-inflammatory and neuroplasticity effects position it as a valuable noninvasive therapeutic option.
- Further research is warranted to optimize patient selection and treatment protocols for HBOT in CRPS.
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