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Related Experiment Video

Updated: May 30, 2025

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
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Risk factors for the involvement of sentinel lymph nodes in endometrial cancer (TRSGO-SLN-010).

Ibrahim Yalcin1, Salih Taskin2, Ozguc Takmaz3

  • 1Division of Gynecologic Oncology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
|January 29, 2025
PubMed
Summary
This summary is machine-generated.

Sentinel lymph node (SLN) involvement in endometrial cancer is predicted by deep myometrial invasion, cervical stromal invasion, and lymphovascular space invasion. These factors are crucial for guiding adjuvant therapy when SLN dissection is not feasible.

Keywords:
Endometrial NeoplasmsLymphatic MetastasisSentinel Lymph Node

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Area of Science:

  • Gynecologic Oncology
  • Surgical Pathology

Background:

  • Endometrial cancer staging often involves sentinel lymph node (SLN) assessment.
  • Identifying predictive factors for SLN involvement is crucial for treatment planning.

Purpose of the Study:

  • To identify clinical and pathological risk factors predicting sentinel lymph node involvement in endometrial cancer patients.

Main Methods:

  • Retrospective analysis of 793 endometrial cancer patients treated with the SLN algorithm across 11 institutions.
  • Logistic regression analysis was used to determine predictive factors for SLN involvement.

Main Results:

  • Sentinel lymph node involvement was observed in 9.2% of cases.
  • Univariate analysis indicated higher risk with age >60, high-grade tumors, non-endometrioid histology, lymphovascular space invasion, deep myometrial invasion, tumor size ≥2 cm, and cervical stromal invasion.
  • Multivariate analysis identified deep myometrial invasion (OR 2.42), cervical stromal invasion (OR 2.18), and lymphovascular space invasion (OR 7.27) as independent predictors of SLN involvement.

Conclusions:

  • Deep myometrial invasion, cervical stromal invasion, and lymphovascular space invasion are independently predictive of SLN involvement in endometrial cancer.
  • These identified risk factors are vital for guiding adjuvant therapy decisions, especially when SLN dissection is not performed.