Demonstration of progestin receptors in human vaginal epithelium

The presence of a high-affinity and limited-capacity progestin receptor was demonstrated in the human vaginal epithelium. The sedimentation coefficients of the receptor were 8.5 S and 5 S. Both nuclear and cytosol progestin receptor concentrations varied considerably during both the follicular and the luteal phase of the cycle. In postmenopausal women no correlation was found between the receptor concentrations and the dose and type of estrogens given.