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Related Concept Videos

Vaccinations01:51

Vaccinations

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Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
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The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible...
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Controlled Human Infection Studies Accelerate Vaccine Development.

Matthew B Laurens1

  • 1Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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Summary
This summary is machine-generated.

Controlled human infection models (CHIMs) accelerate vaccine development by providing rapid efficacy readouts. However, ensuring CHIM study relevance to real-world efficacy trials, especially in resource-limited settings, remains a key challenge.

Area of Science:

  • Infectious disease research
  • Vaccinology
  • Clinical trial methodology

Background:

Keywords:
challengeclinical trialcontrolled human infection modelresearch designvaccine efficacy

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  • Controlled human infection models (CHIMs) are increasingly utilized in vaccine development.
  • CHIMs have been applied to over 30 disease models, demonstrating rapid advancement.
  • These models involve controlled exposure of participants to a pathogen after administration of an investigational product.