A bioactive polysaccharide derived from Rosa laevigata fruits: Structural properties, antitumor efficacy, and...

A heteropolysaccharide, designated JYP70-1, was extracted and purified from the fruits of Rosa laevigata, exhibiting a molecular weight of 1.90 × 10⁴ g/mol. Structural analysis revealed that JYP70-1 was composed of eleven sugar residues, including α-l-Araf-(1→, →3)-α-l-Araf-(1→, →5)-α-l-Araf-(1→, →3,5)-α-l-Araf-(1→, →2,5)-α-l-Araf-(1→, →4)-α-d-Galp-(1→, →6)-β-d-Galp-(1→, →6)-α-d-Glcp-(1→, α-d-Glcp-(1→, →2)-α-d-Manp-(1→, and →3,6)-β-d-Manp-(1→. Following the characterization of the primary structure and conformation of JYP70-1, a series of biological activity assessments were executed, revealing that JYP70-1 significantly inhibited tumor growth and metastasis in a concentration-dependent manner in vivo. Furthermore, a comprehensive array of experiments was strategically designed to elucidate the anti-tumor mechanisms of JYP70-1, focusing on tumor cell migration, angiogenesis, and immune modulation. The identification of the homogeneous polysaccharide JYP70-1 presents a promising candidate for therapeutic applications in oncology.