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Updated: May 30, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
Histone bivalency in CNS development
Kärt Mätlik1,2, Eve-Ellen Govek3, Mary E Hatten1
1Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10065, USA; hatten@rockefeller.edu kart.matlik@taltech.ee.
None:
Neuronal maturation is guided by changes in the chromatin landscape that control developmental gene expression programs. Histone bivalency, the co-occurrence of activating and repressive histone modifications, has emerged as an epigenetic feature of developmentally regulated genes during neuronal maturation. Although initially associated with early embryonic development, recent studies have shown that histone bivalency also exists in differentiated and mature neurons. In this review, we discuss methods to study bivalency in specific populations of neurons and summarize emerging studies on the function of bivalency in central nervous system neuronal maturation and in adult neurons.
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