Related Experiment Video

Updated: May 30, 2025

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima
09:13

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima

Published on: August 12, 2018

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Molecular regulation of mitophagy signaling in tumor microenvironment and its targeting for cancer therapy

Bishnu Prasad Behera1, Soumya Ranjan Mishra1, Srimanta Patra1

  • 1Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Sundergarh, Odisha 769008, India.

Cytokine & Growth Factor Reviews
|January 29, 2025
PubMed

Insights

Mitophagy, a cellular process, is crucial for maintaining mitochondrial health but can drive cancer when dysregulated. Targeting mitophagy offers a promising therapeutic strategy against various cancer types.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Biochemistry

Background:

  • Mitochondrial homeostasis is essential for cellular function and is maintained by mitophagy.
  • Dysregulated mitophagy contributes to cancer development by altering cellular metabolism and promoting survival.
  • The complex role of mitophagy in cancer presents challenges for effective therapeutic interventions.

Purpose of the Study:

  • To review the role of mitophagy in cancer development and progression.
  • To highlight the molecular mechanisms, including receptors, adaptors, and proteins involved in mitophagy during oncogenesis.
  • To explore the potential of targeting mitophagy as a therapeutic strategy for cancer treatment.

Main Methods:

  • Literature review of scientific reports on mitophagy and cancer.
  • Analysis of signaling pathways that modulate mitophagy in cancer cells.
  • Identification of key proteins, receptors, and adaptors in mitophagy-related oncogenesis.

Main Results:

  • Aberrant mitophagy is implicated as a driver of cancer occurrence.
  • Mitophagy modulates the cancer cell proteome, impacting therapeutic responses.
  • Cellular signaling pathways interact with mitophagy to influence cancer progression, stress response, and cell death.

Conclusions:

  • Targeting mitophagy to disrupt oncogenic signaling and induce apoptosis shows potential as an anti-cancer strategy.
  • Understanding the intricate mechanisms of mitophagy in various cancers is key to developing effective therapies.
  • Mitophagy represents a promising therapeutic target for diverse cancer types.
Keywords:
ApoptosisBioenergeticsCancerMitophagyOxidative stress

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