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Electrochemical Denitrative Cyclization Driven by Alternating Polarity
Shuang-Jun Zhu1, Yi-Chao Lin1, Guo-Cai Yuan1
1Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou 350108, China.
Abstract:
Alternating current electrolysis has emerged as a promising technique for addressing challenging redox reactions that are otherwise difficult or impossible for direct current electrolysis. Under mild and transition-metal-free reaction conditions, a general electrochemical denitrative cyclization of nitroarenes was developed to access various cyclic sulfone-containing derivatives of biological significance. The key to success lies in the facile manipulation of multiple redox events upon rapid alternating polarity switching to enhance the selectivity and efficiency.
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Electrolysis
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