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3D-Printed PCL/SrHA@DFO Bone Tissue Engineering Scaffold with Bone Regeneration and Vascularization Function.

Kai Chen1, Liu Luo1, Ruolan Tao1

  • 1School of Materials Science and Physics, School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, Jiangsu, China.

ACS Applied Bio Materials
|January 30, 2025
PubMed
Summary

This study developed a novel 3D-printed composite scaffold using strontium-containing hydroxyapatite (SrHA) and poly(ε-caprolactone) (PCL). The SrHA scaffold enhanced bone cell growth and promoted blood vessel formation, showing promise for bone tissue engineering.

Keywords:
3D printingPCL/SrHA@DFOangiogenesisosteogenesisscaffold

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Bone defect repair necessitates advanced biomaterials.
  • Three-dimensional (3D)-printed scaffolds offer tailored solutions for bone regeneration.
  • Incorporating specific ions and growth factors can enhance scaffold bioactivity.

Purpose of the Study:

  • To synthesize and characterize poly(ε-caprolactone)/strontium-containing hydroxyapatite (PCL/SrHA) composite scaffolds.
  • To evaluate the osteogenic and angiogenic potential of these scaffolds for bone tissue engineering.
  • To investigate the combined effect of SrHA and deferoxamine (DFO) on bone regeneration.

Main Methods:

  • Hydrothermal synthesis of SrHA powder.
  • Fabrication of PCL/HA and PCL/SrHA composite scaffolds using melt extrusion 3D printing.
  • In vitro assessment of physical, chemical, and biological properties.
  • Evaluation of cell proliferation, osteogenic differentiation (MC3T3E1 cells), and angiogenesis (HUVECs).

Main Results:

  • PCL/SrHA scaffolds exhibited a 3D interconnected porous structure with embedded SrHA.
  • Continuous release of Sr²⁺ and Ca²⁺ ions was observed from PCL/SrHA scaffolds.
  • SrHA incorporation significantly promoted osteoblast proliferation and differentiation compared to PCL/HA.
  • DFO-loaded PCL/SrHA scaffolds demonstrated enhanced angiogenesis in vitro, synergistic with Sr²⁺.

Conclusions:

  • The developed PCL/SrHA composite scaffolds possess favorable properties for bone regeneration.
  • The combination of SrHA and DFO shows significant potential for promoting both osteogenesis and angiogenesis.
  • These composite scaffolds represent a promising strategy for bone tissue engineering applications.