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Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study.
Yu-Pei Wang1, Hui-Xia Wei2, Yuan-Yuan Hu3
1Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People's Republic of China.
Nature and Science of Sleep
|January 30, 2025
Summary
Obstructive sleep apnea (OSA) may causally increase the risk of migraine with aura. This research provides new insights for preventing and managing both OSA and migraine.
Area of Science:
- Neurology
- Genetics
- Epidemiology
Background:
- Obstructive sleep apnea (OSA) is frequently comorbid with migraine.
- The etiological relationship between OSA and migraine remains unclear.
- Understanding this relationship is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the potential causal relationship between obstructive sleep apnea and migraine.
- To explore the directionality of this association using Mendelian randomization.
Main Methods:
- Bidirectional two-sample Mendelian randomization (MR) and multivariable MR (MVMR) were employed.
- Genome-wide association study (GWAS) data for OSA and migraine subtypes were analyzed.
- Inverse variance weighted (IVW) analysis and sensitivity tests were conducted.
Main Results:
- Obstructive sleep apnea (OSA) showed a causal association with migraine with aura (MA).
- Multivariable MR confirmed the causal effect of OSA on MA (OR = 1.184, P = 0.020).
- Reverse causality from migraine to OSA was not supported by MVMR analysis.
Conclusions:
- A preliminary causal effect of OSA on migraine with aura was identified in European descendants.
- These findings suggest OSA as a potential contributing factor to MA.
- The study offers new perspectives for the prevention and management of OSA and migraine.
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