Sarcoidosis-Like Reaction in a Patient With Psoriatic Arthritis Treated With Adalimumab

A drug-induced sarcoidosis-like reaction (DISR) is a systemic granulomatous reaction indistinguishable from sarcoidosis and is associated with the administration of a medication. It typically exhibits a temporal relationship with the initiation of the drug (an average interval of 22 months) and tends to improve upon its discontinuation. Tumor necrosis factor (TNF) antagonists, including adalimumab, have been associated with the development of DISR. The case presented here describes a 33-year-old female patient with psoriatic arthritis treated with adalimumab, whose clinical presentation, imaging findings, and histology were consistent with DISR.