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Treatment approaches in advanced penile cancer: targeted therapies and immunotherapy

David J Benjamin1, Robert C Hsu2

  • 1Department of Medical Oncology, Hoag Family Cancer Institute, Newport Beach, CA, United States.

Frontiers in Oncology
|January 30, 2025
PubMed

Insights

Penile cancer, a rare malignancy, is exploring new treatments beyond chemotherapy. Ongoing clinical trials investigate immune checkpoint inhibitors and targeted therapies for advanced disease.

Area of Science:

  • Genitourinary oncology
  • Cancer therapeutics
  • Translational oncology

Background:

  • Penile cancer is a rare genitourinary malignancy.
  • Localized disease is treated with surgery or radiation.
  • Recurrent or metastatic disease typically requires chemotherapy.

Purpose of the Study:

  • To identify novel therapeutic strategies for penile cancer beyond traditional chemotherapy.
  • To explore the potential of emerging treatments in rare cancers.
  • To evaluate the efficacy of immune checkpoint inhibitors and targeted therapies.

Main Methods:

  • Review of current treatment landscape for penile cancer.
  • Analysis of ongoing clinical trials for penile cancer.
  • Investigation of targeted therapies and immune checkpoint inhibitors.

Main Results:

  • Chemotherapy remains a standard for advanced penile cancer.
  • Emerging therapies like immune checkpoint inhibitors are under investigation.
  • Targeted therapies and antibody drug conjugates show promise.

Conclusions:

  • Novel therapeutic avenues are being explored for penile cancer.
  • Immune checkpoint inhibitors and targeted therapies represent promising alternatives.
  • Further research and clinical trials are crucial for advancing penile cancer treatment.
Keywords:
antibody drug conjugateimmune checkpoint inhibitorpenile cancertargeted therapyvaccine

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