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Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: May 30, 2025

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling

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Should We Transplant Candidates With a Positive SARS-CoV-2 RT-PCR Test?

Ilies Benotmane¹, Nathan Kasriel², Christophe Masset³

¹Department of Nephrology Dialysis and Transplantation, Strasbourg University Hospital, INSERM U1109, Strasbourg, France.

Transplantation

|January 30, 2025

Summary

Organ transplantation is safe for patients with a positive SARS-CoV-2 test if they are asymptomatic or have mild symptoms. Outcomes were favorable, with no COVID-19 related deaths in this study of solid organ transplant recipients.

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Published on: April 5, 2018

Area of Science:

Transplant Surgery
Infectious Diseases
Virology

Background:

The safety of solid organ transplantation for SARS-CoV-2 positive candidates is uncertain due to immunosuppression risks.
Physicians face challenges in deciding whether to proceed with transplantation for SARS-CoV-2 positive individuals.

Purpose of the Study:

To evaluate the safety and outcomes of solid organ transplantation in patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test.
To assess the impact of COVID-19 on immunosuppressive therapy and patient outcomes post-transplantation.

Main Methods:

A multicenter observational study included 65 liver or kidney transplant candidates with a positive SARS-CoV-2 test.
Data collected included patient demographics, COVID-19 symptoms, viral load (cycle threshold), serology, and treatment modifications.

Main Results:

Most patients were male (62%) with a mean age of 55.4 years.
Only 2 patients had symptoms, and 3 showed imaging compatible with COVID-19.
Outcomes were generally favorable, even with high viral loads; no deaths were attributed to COVID-19.

Conclusions:

Solid organ transplantation can be safely performed in asymptomatic or mildly symptomatic patients with a positive SARS-CoV-2 test.
A history of SARS-CoV-2 infection or immunization, alongside reassuring imaging, supports transplantation safety.