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Differences in Combustible Cigarette Smoking-Related Biomarkers by Hormonal Contraceptive Use: An Exploratory Study.
Alicia M Allen1, Qing Cao2, Lori G Stayer2
1Department of Family & Community Medicine, College of Medicine - Tucson, University of Arizona, Tucson, AZ, USA.
Hormonal contraceptives containing ethinyl estradiol may influence smoking biomarkers, while progestin-only contraceptives do not appear to alter them. This study compared smoking biomarkers in women using different types of hormonal contraceptives.
Area of Science:
- Reproductive Health
- Nicotine Metabolism
- Biomarker Analysis
Background:
- Hormonal contraceptives (HCs) are widely used by women who smoke.
- While estrogen's effect on nicotine metabolism is known, progestin's role is less understood.
- This study investigated HC use and smoking-related biomarkers.
Purpose of the Study:
- To examine the association between hormonal contraceptive (HC) use and smoking-related biomarkers.
- To compare biomarkers in users of combination HCs (C-HC), progestin-only HCs (P-HC), and non-users (no-HC).
Main Methods:
- Exploratory analysis of females (18-45) who currently smoke.
- Classified participants into C-HC, P-HC, and no-HC groups.
- Assessed expired carbon monoxide, NNAL, NMR, TNE, and TNE/cigarette ratio.
Main Results:
- No significant differences in biomarkers between P-HC and no-HC groups.
- Combination HCs (C-HC) users showed significantly lower Total Nicotine Equivalent (TNE) compared to P-HC and no-HC groups.
- Adjusted analyses confirmed lower TNE in the C-HC group.
Conclusions:
- Progestin-only HCs did not alter smoking-related biomarkers compared to no HC use.
- HCs containing ethinyl estradiol were associated with lower Total Nicotine Equivalent (TNE).
- Further research is needed to confirm these findings on hormonal contraceptive impact on smoking biomarkers.
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