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Related Experiment Videos

Delayed gastric emptying with dothiepin.

K W Woodhouse, D N Bateman

    Human Toxicology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Dothiepin, an antidepressant, caused delayed gastric emptying in an elderly patient. This suggests older individuals may be more sensitive to the gut-related side effects of tricyclic antidepressants.

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    Area of Science:

    • Pharmacology
    • Geriatric Medicine
    • Gastroenterology

    Background:

    • Tricyclic antidepressants (TCAs) are commonly prescribed for various conditions.
    • Anticholinergic side effects are known adverse reactions to TCAs.
    • Delayed gastric emptying can lead to gastrointestinal complications.

    Observation:

    • An elderly female patient presented with symptoms indicative of delayed gastric emptying.
    • The patient was administered dothiepin, a TCA medication.
    • Rechallenge with dothiepin confirmed the drug-induced nature of the gastric emptying delay.

    Findings:

    • Dothiepin administration resulted in significantly delayed gastric emptying of liquids.
    • The delay was observed at a plasma concentration of 93 micrograms/l.

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  • This indicates a direct pharmacological effect of dothiepin on gastric motility.

    • Implications:

    • Elderly patients may exhibit increased susceptibility to the anticholinergic effects of TCAs on the gastrointestinal tract.
    • Clinical monitoring for gastric emptying disturbances is crucial in elderly patients receiving TCAs.
    • Further research into TCA pharmacodynamics in geriatric populations is warranted to optimize treatment strategies.