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A contribution to the question of genetic transmission of immunological tolerance
In view of the discrepancy in the results concerning the question of inheritance of immunological tolerance, we tried to enhance the genetic effect of tolerization by tolerizing male mice over three succeeding generations and by testing the ability of their progeny to reject an allogeneic tumour graft. This highly sensitive in vivo test, even of partial tolerance, did not reveal any difference in allogeneic tumour growth between progeny of control and tolerized males. Thus, the results again did not confirm genetic transmission of induced tolerance. The possible causes of the discrepancy between the results reported here and the results obtained by others are considered.
In view of the discrepancy in the results concerning the question of inheritance of immunological tolerance, we tried to enhance the genetic effect of tolerization by tolerizing male mice over three succeeding generations and by testing the ability of their progeny to reject an allogeneic tumour graft. This highly sensitive in vivo test, even of partial tolerance, did not reveal any difference in allogeneic tumour growth between progeny of control and tolerized males. Thus, the results again did not confirm genetic transmission of induced tolerance. The possible causes of the discrepancy between the results reported here and the results obtained by others are considered.