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Updated: May 30, 2025
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
Natural compounds as modulators of miRNAs: a new frontier in bladder cancer treatment
Ahmed I Abulsoud1,2, Shaza H Aly3, Sherif S Abdel Mageed4
1Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, 11231, Egypt.
Abstract:
Bladder cancer (BC) is a major global health issue with a high recurrence rate and limited effective treatments. Over the past few years, it has become evident that miRNAs play a role in the carcinogenesis process, particularly in regulating genes that promote cancer cell proliferation and invasion. This review focuses on the extent to which natural products can act as potential miRNA modulators for the management of bladder cancer. Polyphenols, flavonoids, and other phytochemicals are natural compounds found to have inherent potential to modulate miRNAs and reform the oncogenic properties of bladder cancer cells regulating cell growth and death. In integration with the current cancer treatment regimes, such natural agents may safely substitute for the traditional chemical chemotherapeutic agents of the conventional approaches. To this end, this review presents the existing knowledge of natural compounds as regulators of miRNA, their mechanisms for the management of BC, the role of their nanoparticles, and future novel therapies. The use of these compounds is not only a therapeutic practice for the conditions of bladder cancer, but it also upholds new avenues for creativity.
Insights
Natural compounds, including polyphenols and flavonoids, show promise in modulating microRNAs (miRNAs) for bladder cancer (BC) treatment. These agents offer a potentially safer alternative to traditional chemotherapy by regulating cancer cell growth and death.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Bladder cancer (BC) presents a significant global health challenge with high recurrence rates and limited therapeutic options.
- MicroRNAs (miRNAs) are increasingly recognized for their role in bladder cancer development, influencing cell proliferation and invasion.
- Current treatments for BC often involve chemotherapy, which can have significant side effects.
Purpose of the Study:
- To review the potential of natural products as modulators of miRNAs for bladder cancer management.
- To explore the mechanisms by which phytochemicals influence cancer cell properties.
- To discuss the integration of natural compounds into existing BC treatment strategies.
Main Methods:
- Literature review of studies investigating natural compounds and their effects on miRNAs in bladder cancer.
- Analysis of research on polyphenols, flavonoids, and other phytochemicals.
- Examination of the role of nanoparticles in delivering natural compounds.
Main Results:
- Natural products like polyphenols and flavonoids possess inherent miRNA-modulating capabilities.
- These compounds can reverse oncogenic properties of bladder cancer cells by regulating cell growth and apoptosis.
- Nanoparticle formulations enhance the delivery and efficacy of these natural agents.
Conclusions:
- Natural compounds represent a promising avenue for bladder cancer therapy through miRNA modulation.
- Phytochemicals offer a potentially safer and effective alternative or adjunct to conventional chemotherapy.
- Further research into natural compounds and their nanoparticle delivery systems could lead to novel BC treatments.
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