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Related Experiment Videos

Tolbutamide kinetics in a normal Indian population.

R Uppal, P L Sharma

    International Journal of Clinical Pharmacology, Therapy, and Toxicology
    |February 1, 1985
    PubMed
    Summary

    This study compared tolbutamide half-life in healthy males and females. Female subjects showed a longer plasma tolbutamide half-life, though the difference was not statistically significant.

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    Area of Science:

    • Pharmacokinetics
    • Clinical Pharmacology
    • Drug Metabolism

    Background:

    • Tolbutamide is an oral hypoglycemic agent used in type 2 diabetes.
    • Understanding pharmacokinetic differences, such as drug half-life, between sexes is crucial for personalized medicine.

    Purpose of the Study:

    • To investigate potential sex-based differences in the plasma tolbutamide half-life.

    Main Methods:

    • A single oral dose of 500 mg tolbutamide was administered to 13 healthy volunteers.
    • Plasma concentrations of tolbutamide were monitored over time.
    • Half-life was calculated and compared between male and female participants.

    Main Results:

    • The mean plasma tolbutamide half-life was observed to be longer in female subjects compared to male subjects.
    • This observed difference in half-life between sexes did not reach statistical significance (p > 0.05).

    Conclusions:

    • While a trend towards a longer tolbutamide half-life in females was noted, the difference was not statistically significant in this cohort.
    • Further research with larger sample sizes may be warranted to definitively establish any sex-based pharmacokinetic variations for tolbutamide.

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