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Updated: Jun 14, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Diagnostic utility of next-generation sequencing in neurological infections: Two cases in point
Ravi Teja Kandikuppa1, Vidya Krishna1, Nandini Sethuraman2
1Department of Infectious Diseases, Apollo Hospitals, Chennai, 600006, India.
Abstract:
We report the successful management of two cases of brain abscess and subdural empyema caused by Fusobacterium nucleatum and Streptococcus intermedius diagnosed using 16S ribosomal RNA (rRNA) sequencing where microbiological culture showed no growth. This report elucidates the utility of next-generation sequencing (NGS) in determining the microbial etiology and guiding appropriate antimicrobial treatment in life-threatening neurological infections.

