Outcomes After Surgical Management of Early-Stage Lung Cancer in Octogenarians: An In-Depth Analysis of a Nationally...

As the United States population ages more octogenarians are undergoing surgical resection for lung cancer. We aimed to provide an updated and expanded assessment of age-related risks associated with surgical resections for early-stage NSCLC.

The Surveillance, Epidemiology, and End Results and Medicare databases were queried for stage IA NSCLC cases treated by surgery between 2006 and 2018. Analyses included generalized linear models for one-year mortality and Cox proportional hazards models for five-year survival.

One-year all-cause mortality among 4061 octogenarians was more than double that of the youngest group (age: 65-69 y): 15.2% versus 7.3%, p value less than 0.001. Octogenarians were discharged to extended skilled nursing facility stays more than three times as often as the youngest group (19.9% versus 6.3%, p < 0.001). For those with skilled nursing facility duration greater than 30 days, there was a 36% greater one-year mortality risk compared with those discharged to home or home-health. In adjusted analyses, octogenarians had 62% greater one-year mortality risk compared with those aged below 80 years (risk ratio = 1.62, 95% confidence interval: 1.48-1.78). The risk of death within five years was 52% higher (hazard ratio = 1.52, 95% confidence interval: 1.42-1.62). Additional factors associated with one-year mortality included male sex, higher comorbidity burden, lower county median income, open approach, and sub-lobar resection.

This analysis provides an updated and expanded characterization of age-related outcomes on the basis of a large national cohort representative of elderly patients treated outside of clinical trials. Substantial gaps in survival and discharge disposition motivate further research and the development of interventions to help improve outcomes in older patients.