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Development of an In Vitro Ocular Platform to Test Contact Lenses
08:28

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Published on: April 6, 2016

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Smart theranostic contact lenses.

Seong-Jong Kim1, Jin Huh1, Sei Kwang Hahn1

  • 1Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Republic of Korea.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 30, 2025
PubMed
Summary

Smart contact lenses show promise for theranostics, offering biomarker detection and drug delivery. Challenges in clinical development and commercialization need addressing for personalized medicine applications.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Materials Science

Background:

  • Smart contact lenses offer advanced theranostic capabilities, integrating sensing and drug delivery.
  • Current research highlights potential in detecting biomarkers like glucose, intraocular pressure (IOP), and inflammatory cytokines.
  • These lenses also function as drug delivery systems (DDS) for targeted ocular therapy.

Purpose of the Study:

  • To review the current status and capabilities of smart theranostic contact lenses.
  • To discuss challenges and opportunities in clinical development and commercialization.
  • To explore future directions for personalized medicine applications.

Main Methods:

  • Perspective-based review of existing literature and technological advancements.
  • Analysis of smart contact lens applications in sensing and drug delivery.
  • Discussion of clinical, regulatory, and manufacturing hurdles.

Main Results:

  • Smart contact lenses are advancing as integrated diagnostic and therapeutic platforms.
  • Key applications include continuous glucose monitoring, IOP tracking, and cytokine detection.
  • Controlled drug delivery for ocular conditions is a significant capability.

Conclusions:

  • Smart theranostic contact lenses hold significant potential for personalized ocular medicine.
  • Addressing safety, efficacy, and mass-production challenges is crucial for commercialization.
  • Further research is needed to establish these lenses as versatile platforms for advanced healthcare.