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Updated: May 30, 2025

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
Published on: November 3, 2016
Cerebellar Development and the Burden of Prematurity
Tobias Muehlbacher1, Jeroen Dudink2, Sylke J Steggerda3
1Department of Neonatology, Newborn Research Zurich, University Hospital Zurich, Zurich, Switzerland. Tobias.Muehlbacher@usz.ch.
Abstract:
The role of the cerebellum in the neurodevelopmental outcomes of preterm infants has often been neglected. However, accumulating evidence indicates that normal cerebellar development is disrupted by prematurity-associated complications causing cerebellar injury and by prematurity itself. This hampers not only the normal development of motor skills and gait, but also cognitive, language, and behavioral development, collectively referred to as "developmental cognitive affective syndrome." In this comprehensive narrative review, we provide the results of an extensive literature search in PubMed and Embase to summarize recent evidence on altered cerebellar development in premature infants, focusing on neuroimaging findings, its causative factors and its impact on long-term neurodevelopmental outcomes.
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