The use of fluorescence microscopy and microfluorimetry to study the distribution of quinacrine in mice

A simple method was used to prepare cryostat-cut sections in which quinacrine-induced fluorescence could be seen by fluorescence microscopy. Such sections were used in preliminary studies of the distribution of this drug in mice. Micro-fluorimetry was used to quantify the fluorescence. The method may be of value in the detection of drugs in various fields.