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Leukoglycemic Index and Its Prognostic Implications in Diabetic and Nondiabetic Patients with Acute Pulmonary

Nuray Aslan1, Fatih Güneysu2, Yusuf Yürümez2

  • 1Department of Emergency Medicine, Sakarya University Education and Research Hospital, Adapazarı, Turkey.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|January 31, 2025
PubMed

Insights

The leuko-glycemic index (LGI) did not predict mortality in acute pulmonary embolism (APE) patients, regardless of diabetes status. Higher mortality was observed in diabetic APE patients, but LGI was not a significant prognostic factor.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pulmonology

Background:

  • The leuko-glycemic index (LGI) combines white blood cell count and blood glucose levels.
  • Acute pulmonary embolism (APE) is a significant cause of morbidity and mortality.
  • Diabetes mellitus is a known risk factor for cardiovascular events and may influence APE outcomes.

Purpose of the Study:

  • To evaluate the prognostic value of the LGI in patients with APE.
  • To compare the LGI's predictive ability for mortality in APE patients with and without diabetes mellitus.

Main Methods:

  • Retrospective study of 199 patients diagnosed with APE.
  • Patients were categorized into diabetic and non-diabetic groups.
  • Analysis of all-cause mortality within 30 days based on LGI cut-off values.

Main Results:

  • Mortality rates were higher in the diabetic APE patient group.
  • A simplified Pulmonary Embolism Severity Index score ≥1 independently predicted mortality in non-diabetic patients.
  • The LGI was not found to be an independent predictor of 30-day all-cause mortality in either diabetic or non-diabetic APE patients.

Conclusions:

  • Diabetes is associated with increased mortality in APE patients.
  • The LGI does not appear to be a reliable independent predictor of mortality in APE patients.
  • Further research is warranted to validate these findings due to limited existing studies on LGI in APE.

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