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Updated: May 30, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Linear approximation of variable relative biological effectiveness models for proton therapy
Dirk Wagenaar1, Johannes A Langendijk1, Stefan Both1
1Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Abstract:
The McNamara (MCN) and Wedenberg (WED) RBE weighted dose (DRBE), dose and dose-weighted average LET (LETd) were calculated in twenty brain cancer patients. A linear approximation was made for each RBE model to give best agreement to clinically relevant dosimetric parameters. Additional evaluations were done on twenty head and neck and twenty breast cancer patients.The R2 of the fits was ≥0.94 and ≥0.91 for MCN and WED respectively for α/β values ≥1.0 Gy. The graphs derived in this work can be used to convert RBE-LET slopes derived from clinical data to α/β values in the MCN or WED models.
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