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Updated: May 30, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

498

Understanding Diabetic Cardiomyopathy: Insulin Resistance and Beyond

Aditya John Binu1, Nitin Kapoor2,3

  • 1Department of Cardiology, Christian Medical College & Hospital, Vellore, Tamil Nadu, India.

Heart International
|January 31, 2025
PubMed

Insights

Diabetic cardiomyopathy (DC) is an underdiagnosed heart condition in diabetes mellitus (DM). Understanding its molecular mechanisms, including inflammation and insulin resistance, is key to developing new diagnostic and treatment strategies.

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • Diabetic cardiomyopathy (DC) is a heart failure syndrome in diabetes mellitus (DM) patients, independent of other risk factors.
  • DC is often underdiagnosed due to a prolonged subclinical phase.
  • Numerous studies investigate the pathogenic mechanisms underlying DC.

Purpose of the Study:

  • To review and summarize current medical literature on the molecular mechanisms, signaling and metabolic abnormalities, and structural/functional changes in DC.
  • To elucidate postulated pathogenic mechanisms of DC beyond insulin resistance.

Main Methods:

  • Conducted a literature search using terms like 'diabetic cardiomyopathy' and 'heart failure AND Diabetes mellitus'.
  • Reviewed reference lists of included studies and relevant systematic reviews.

Main Results:

  • Elucidated various postulated mechanisms in DC pathogenesis, including insulin resistance, inflammation, renin-angiotensin-aldosterone system activation, and disrupted protein homeostasis.
  • Summarized molecular, signaling, metabolic, structural, and functional abnormalities associated with DC.

Conclusions:

  • Diabetic cardiomyopathy is an underrecognized cardiac complication of diabetes mellitus.
  • Comprehensive knowledge of DC pathways and mediators can facilitate the development of diagnostic/prognostic markers, screening protocols, and novel therapies.

Keywords:
Diabetic cardiomyopathydiabetes complicationsdiabetes mellitusheart failureleft ventricular dysfunctionventricular remodelling

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