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Updated: May 30, 2025

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

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HIV-1 Vif global diversity and possible APOBEC-mediated response since 1980.

Eric Lewitus1,2, Yifan Li1,2, Morgane Rolland1,2

  • 1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA.

Virus Evolution
|January 31, 2025
PubMed
Summary

HIV-1 Vif protein counters APOBEC3 enzymes. While Vif evolves, selection doesn't target APOBEC3 sites, suggesting rare Vif adaptation to this pressure. HIV-1 diversity may arise from other mechanisms.

Keywords:
APOBEC3HIV-1Vifhypermutationphylogenetics

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