POEMS Syndrome Presenting as First-Time Heart Failure Exacerbation
Michael Brandt1, Alexandra Allman1, Hayan Jouni2
1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
JACC. Case Reports
|January 31, 2025
Summary
A 40-year-old man with heart failure exacerbation was diagnosed with POEMS syndrome. This rare disorder involves polyneuropathy, organomegaly, endocrinopathy, and skin changes.
Area of Science:
- Cardiology
- Neurology
- Hematology
Background:
- Heart failure exacerbation can present with diverse underlying etiologies.
- POEMS syndrome is a rare multisystem disorder requiring multidisciplinary diagnosis.
Observation:
- A 40-year-old male presented with symptoms indicative of heart failure exacerbation.
- Initial investigations did not immediately reveal the underlying cause.
Findings:
- The patient was ultimately diagnosed with POEMS syndrome.
- This diagnosis was based on the characteristic features of polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes.
Implications:
- Highlights the importance of considering rare systemic diseases in heart failure presentations.
- Emphasizes the need for comprehensive diagnostic workups for complex cases.
- Underscores the diagnostic challenges and multidisciplinary approach required for POEMS syndrome.
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