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Advances in Scaffolds and Additives for Infection Control in Autologous Chondrocyte Transplantation
Nazmia Nassereddine1, Rena Roda1, Rami Mhanna1
1Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon.
Tissue Engineering. Part B, Reviews
|January 31, 2025
Summary
Infection control in cartilage tissue engineering (CTE) is crucial for successful regenerative medicine. This review highlights antimicrobial scaffolds like chitosan and chondroitin sulfate, and additives such as zinc, silver, and copper for enhanced implant safety.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Infectious Disease Control
Background:
- Cartilage tissue engineering (CTE) offers advancements in regenerative medicine, particularly for cartilage repair.
- Implant-associated infections pose a significant challenge, hindering surgical success and patient recovery in CTE.
- Existing CTE strategies require enhanced infection control measures for improved clinical outcomes.
Purpose of the Study:
- To provide a comprehensive overview of antimicrobial strategies for infection prevention in cartilage tissue engineering.
- To identify and evaluate scaffolds and additives with antibacterial properties suitable for CTE applications.
- To offer a practical foundation for researchers aiming to mitigate infection risks in cartilage implants.
Main Methods:
- Review of current cartilage tissue engineering scaffolds, focusing on those with inherent antimicrobial properties.
- Identification and assessment of additives for CTE scaffolds based on chondrocyte compatibility, scaffold suitability, and antibacterial efficacy.
- Analysis of materials including chitosan, chondroitin sulfate, zinc oxide, silver, and copper for their potential in infection control.
Main Results:
- Chitosan and chondroitin sulfate are identified as promising antimicrobial scaffolds with good biocompatibility.
- Chitosan, zinc oxide, silver, and copper demonstrate significant potential as additives due to chondrocyte compatibility and antibacterial efficacy.
- The review establishes practical criteria for selecting effective antimicrobial agents in CTE.
Conclusions:
- Antimicrobial scaffolds and additives are essential for enhancing the safety and efficacy of cartilage tissue engineering.
- Chitosan, chondroitin sulfate, zinc oxide, silver, and copper represent key materials for developing infection-resistant cartilage implants.
- Further research into novel materials and fabrication processes is needed to optimize infection control in CTE and improve patient outcomes.
