Related Experiment Video

Updated: May 30, 2025

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

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Neurodevelopmental Impairments as Long-term Effects of Iron Deficiency in Early Childhood: A Systematic Review

Jason Theola1, Murti Andriastuti2

  • 1Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia

Balkan Medical Journal
|January 31, 2025
PubMed

Insights

Early iron deficiency (ID) in children leads to lasting neurodevelopmental problems. Preventing ID in the first 1,000 days is crucial for healthy cognitive, motor, and behavioral development.

Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Nutritional Science

Background:

  • Numerous studies link early-life iron deficiency (ID) to neurodevelopmental disorders in children, but findings are inconsistent.
  • Early childhood ID can have significant long-term effects on a child's development.

Approach:

  • A systematic review was conducted using data from five electronic databases.
  • Keywords included “iron deficiency anemia” and “infant.”
  • Seventeen cohort studies were appraised for quality using the JBI critical appraisal tool.

Key Points:

  • Seventeen cohort studies were identified, with 14 rated high quality and 3 moderate quality.
  • Neurodevelopmental domains assessed included cognitive, motor, verbal, behavioral, auditory, and neuroendocrine functions.
  • Children with early-life ID showed poorer outcomes in cognitive, motor, and behavioral domains.

Conclusions:

  • Early-life ID significantly disrupts neurodevelopment, causing persistent impairments.
  • Preventing iron deficiency within the first 1,000 days is critical to avoid irreversible deficits.
  • Intervention is essential to mitigate long-term negative impacts on cognitive, motor, and behavioral functions.
Abstract

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