Related Experiment Video

Updated: May 30, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

6.1K

CircPTK2 as a Valuable Biomarker and Treatment Target in Cancer

Chengqiu Yan1, Yu Du1, Lihong Cui1

  • 1Department of Anorectal Center, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.

Journal of Biochemical and Molecular Toxicology
|January 31, 2025
PubMed

Insights

Circular RNAs (CircRNAs) regulate tumor development and aggressiveness. Circular RNA protein tyrosine kinase 2 (circPTK2) shows increased expression in cancers, linking it to poor prognosis and potential as a diagnostic and therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Circular RNAs (CircRNAs) are novel noncoding RNAs implicated in cancer development and progression.
  • Abnormal circRNA expression is observed in various human cancers, including bladder, liver, breast, and gastric cancers.
  • CircRNAs act as microRNA (miRNA) sponges, influencing posttranscriptional gene regulation in cancer.

Purpose of the Study:

  • To review the biosynthesis and characteristics of circRNAs.
  • To examine the role of circular RNA protein tyrosine kinase 2 (circPTK2) in cancer.
  • To assess circPTK2's potential in cancer diagnosis, treatment, and prognosis.

Main Methods:

  • Literature review of circRNA biosynthesis and function.
  • Analysis of studies reporting circPTK2 expression and clinical significance.
  • Investigation of circRNA-miRNA interactions in cancer.

Main Results:

  • CircRNAs are produced via back-splicing and are protected from degradation, making them promising biomarkers.
  • Elevated circPTK2 expression correlates with adverse clinical features and poor prognosis in multiple cancers.
  • CircPTK2's role as a miRNA sponge affects cancer progression.

Conclusions:

  • Understanding circRNA mechanisms, particularly circPTK2, is crucial for developing novel cancer therapies and biomarkers.
  • CircPTK2 holds potential for improving cancer diagnosis, treatment strategies, and prognosis evaluation.
  • Further research into circRNA biology can advance oncology and personalized medicine.
Keywords:
CircPTK2CircRNAbiomarkercancerdiagnosis

More Related Videos

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

7.9K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.2K

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K