Effects of Static and Low-Frequency Magnetic Fields on Gene Expression

Area of Science:

• Biophysics
• Molecular Biology
• Cell Biology

Background:

• Magnetic fields influence cellular processes, including gene expression.
• Understanding the mechanisms of biomagnetic effects is limited due to small magnetic forces acting on cells.
• This hinders the development of therapeutic applications of magnetic fields.

Purpose of the Study:

• To review the literature on genetic events during static and low-frequency magnetic field exposure.
• To explore intracellular mechanisms linking magnetic fields to gene expression changes.
• To identify knowledge gaps and suggest future research directions.

Main Methods:

• Systematic literature review using extensive search strategies across multiple databases.
• Analysis of studies investigating genetic events under magnetic field exposure.
• Exploration of intracellular mechanisms and cellular signaling pathways.

Main Results:

• Magnetic fields can alter gene expression through interactions with cellular machinery.
• Specific intracellular mechanisms of transcription modification by magnetic fields are being elucidated.
• Connections between magnetic fields and altered gene expression are established in various contexts.

Conclusions:

• Further research is needed to fully understand the molecular mechanisms of biomagnetic effects.
• Elucidating these mechanisms will facilitate the development of novel magnetic field-based therapies.
• Future studies should focus on the interplay between magnetic fields, gene expression, and cellular signaling.