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Temporal Association Cortex Gates Sound-Evoked Arousal from NREM Sleep
Haipeng Yu1,2, Jincheng Wang2, Ruiqi Pang3
1Advanced Institute for Brain and Intelligence, School of Physical Science and Technology, Guangxi University, Nanning, 530004, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 31, 2025
Summary
Neurons in the temporal association cortex (TeA) gate sound-evoked arousal from non-rapid eye movement (NREM) sleep. This circuit selectively controls wakefulness, highlighting TeA
Area of Science:
- Neuroscience
- Sleep Research
- Auditory Processing
Background:
- Sound-evoked wakefulness is vital but its neural basis is unclear.
- CaMKIIα+ neurons in the temporal association cortex (TeA) are investigated for their role in arousal.
Purpose of the Study:
- To elucidate the neural mechanisms of sound-evoked arousal from sleep.
- To determine the role of TeA CaMKIIα+ neurons in regulating wakefulness.
Main Methods:
- Optogenetic activation and manipulation of TeA neurons in mice.
- In vivo electrophysiological and calcium recordings.
- Analysis of neural tuning to sound intensity and frequency.
- Investigation of downstream targets and brain oscillations.
Main Results:
- TeA CaMKIIα+ neurons are not essential for natural awakening but can induce wakefulness from NREM sleep via optogenetic stimulation.
- TeA neurons show monotonic tuning to sound intensity.
- Baseline excitability of TeA neurons and delta oscillations influence sound-evoked arousal.
- Projections from TeA to the amygdala are critical for modulating sound-evoked arousal.
Conclusions:
- A top-down regulatory circuit involving TeA selectively governs sound-evoked arousal from NREM sleep.
- The TeA acts as a crucial cortical hub connecting to subcortical regions for arousal control.
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