Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

56.9K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
56.9K
Neurulation01:30

Neurulation

41.8K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.8K
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

4.2K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
4.2K
Development of the Lymphatic System01:15

Development of the Lymphatic System

587
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
587
Anatomy of the Intestines01:23

Anatomy of the Intestines

71.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.6K
Large Intestine01:09

Large Intestine

595
The large intestine is divided into three main regions: the cecum, colon, and rectum. Extending from the ileocecal valve to the anus, it frames the small intestine on three sides.
The ileocecal sphincter, a mucous membrane fold, guards the opening from the ileum to the large intestine. This valve permits material from the small intestine to pass into the large intestine. Attached to the ileocecal valve is the cecum. This small pouch, approximately 6 cm long, has a twisted, coiled tube known as...
595

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Usefulness of indigo carmine chromoendoscopy for detecting gastric cancer and gastric adenoma during upper gastrointestinal endoscopy (INDIGO study): protocol for a prospective multicentre observational study.

BMJ open gastroenterology·2026
Same author

CT- and MR Imaging-based Radiomics Approach to Differentiating Ovarian Mature and Immature Teratomas: Can MR Imaging-based Radiomics Predict the Histological Grade of Immature Teratomas?

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine·2026
Same author

Prenatal sexual dimorphism in human pelvic tilt at the onset of fetal ossification.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same author

Morphogenesis of the Extraocular Muscles During the Human Embryonic and Early Fetal Periods.

Congenital anomalies·2026
Same author

Determinants of midgut loop formation: Influence of midgut length, diameter, and location.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same author

Noise-Matched Blending Level Selection for 1024-Matrix CT Images Using Hybrid-Iterative Reconstruction: Comparison With 512-Matrix Images.

Journal of computer assisted tomography·2026

Related Experiment Video

Updated: Jun 15, 2025

Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse
07:41

Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse

Published on: April 17, 2019

9.9K

Hierarchical loop formation in human midgut during physiological umbilical herniation.

Nanase Ishida1, Yui Ueda1, Toru Kanahashi1

  • 1Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Journal of Anatomy
|January 31, 2025
PubMed
Summary

Human embryonic midgut development involves primary, secondary, and tertiary loop formation. Biomechanical factors, like rapid midgut elongation and slow mesenteric growth, drive tertiary loop development during herniation.

Keywords:
human embryointestinal loop formationmidgutumbilical herniation

More Related Videos

Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of Villus Development
06:46

Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of Villus Development

Published on: September 4, 2014

14.9K
Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

1.2K

Related Experiment Videos

Last Updated: Jun 15, 2025

Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse
07:41

Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse

Published on: April 17, 2019

9.9K
Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of Villus Development
06:46

Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of Villus Development

Published on: September 4, 2014

14.9K
Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

1.2K

Area of Science:

  • Developmental Biology
  • Embryology
  • Anatomy

Background:

  • The midgut undergoes significant morphological changes during human embryonic development.
  • Understanding these changes is crucial for identifying congenital anomalies.

Purpose of the Study:

  • To describe the morphological alterations in the midgut and mesentery during the herniated phase.
  • To analyze the formation and development of primary, secondary, and tertiary midgut loops.

Main Methods:

  • High-resolution magnetic resonance imaging (MRI) of 47 human embryos (Carnegie stages 16-23) and 2 fetuses.
  • Histological observation of serial tissue sections from four embryos.
  • Three-dimensional reconstruction and analysis of the midgut and mesentery.

Main Results:

  • Primary loop formation observed between CS16-18.
  • Secondary loops discerned at CS19 in segments S2 and S4.
  • Tertiary loops first identified at CS21 in S2 or S3, with delayed formation in S4.
  • Loop formation is influenced by crown-rump length and biomechanical factors.

Conclusions:

  • Tertiary loop development is driven by the biomechanical interplay of rapid midgut elongation and slow mesenteric growth.
  • This study provides insights into the roles of genetic and biomechanical factors in embryonic midgut loop formation.