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Analysis of TNS3-203 and LRRFIP1-211 Transcripts as Oral Cancer Biomarkers
Katarina Zeljic1, Dunja Pavlovic2, Goran Stojkovic3,4
1Faculty of Biology, University of Belgrade, Belgrade, Serbia.
Summary
The TNS3-203 transcript shows diagnostic potential for oral cancer, being significantly overexpressed in tumors. However, LRRFIP1-211 did not demonstrate diagnostic or prognostic value in this study.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- Differential promoter activity of TNS3 and LRRFIP1 genes in head and neck squamous cell carcinoma (HNSCC) was previously identified.
- Specific transcripts, TNS3-203 and LRRFIP1-211, were found to be upregulated by these promoters in HNSCC.
Purpose of the Study:
- To evaluate the potential of TNS3-203 and LRRFIP1-211 transcripts as diagnostic and prognostic biomarkers in oral cancer.
- To investigate the role of these transcripts in the context of oral carcinogenesis.
Main Methods:
- In silico analysis was performed to characterize the promoters and transcripts.
- Quantitative real-time PCR (qRT-PCR) was used to measure the relative expression of TNS3-203 and LRRFIP1-211.
- Expression levels were compared between oral cancer tissues and adjacent non-cancerous tissues from 46 patients.
Main Results:
- TNS3-203 transcript was significantly overexpressed in oral cancer tissues compared to matched non-cancerous tissues.
- No significant difference in LRRFIP1-211 transcript levels was observed between cancer and non-cancerous tissues.
- Neither TNS3-203 nor LRRFIP1-211 transcripts showed prognostic potential in oral cancer.
Conclusions:
- The TNS3-203 transcript exhibits potential as a diagnostic biomarker for oral cancer.
- The LRRFIP1-211 transcript does not appear to have diagnostic or prognostic utility in oral cancer.
- Further research is warranted to elucidate the role of TNS3-203 in oral carcinogenesis.
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