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Double-Layer Microneedle Patch Loaded with HA-PBA-QCT for Management of Paclitaxel-Induced Peripheral Neuropathic
Yunfan Kong1,2, Tianshu Pan1,2, Bo Liu1,2
1Mary & Dick Holland Regenerative Medicine Program University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Small (Weinheim an Der Bergstrasse, Germany)
|January 31, 2025
Summary
New microneedle patches deliver quercetin to effectively reduce chemotherapy-induced neuropathic pain (CINP) by targeting neuroinflammation and oxidative stress. This innovative approach offers sustained relief for patients experiencing this common chemotherapy side effect.
Area of Science:
- Biomaterials Science
- Neuroscience
- Pharmacology
Background:
- Chemotherapy-induced neuropathic pain (CINP) is a debilitating side effect of cancer treatment, often caused by agents like paclitaxel (PTX).
- PTX damages the nervous system via neuroinflammation and oxidative stress, leading to pain sensitization.
- Quercetin (QCT) possesses anti-inflammatory, antioxidant, and neuroprotective properties relevant for neurological disorders.
Purpose of the Study:
- To develop and evaluate a novel drug delivery system for quercetin to treat chemotherapy-induced neuropathic pain.
- To investigate the efficacy of quercetin-loaded microneedle (QMN) patches in alleviating pain and underlying pathological mechanisms in a mouse model.
Main Methods:
- Fabrication of double-layer microneedle (MN) patches using hyaluronic acid-phenylboronic acid (HA-PBA) gels loaded with quercetin (QCT) and a HA/polyvinyl alcohol (PVA) substrate.
- Controlled and sustained release of QCT from the MN patches through crosslinking between PVA and HA-PBA-QCT.
- Application of QMN patches to the instep skin of paclitaxel-treated mice exhibiting mechanical allodynia and cold hyperalgesia.
Main Results:
- Biweekly QMN patch application significantly reduced pain responses in PTX-treated mice.
- Analgesic effects were linked to modulated satellite glial cell activity, reduced macrophage infiltration, and decreased pro-inflammatory cytokines (TNF-α, IL-6) in dorsal root ganglia (DRGs).
- Treatment upregulated antioxidant markers (Nrf2, catalase) in DRGs, indicating improved cellular antioxidant capacity.
Conclusions:
- Double-layer QMN patches provide a promising strategy for sustained quercetin delivery.
- This approach effectively alleviates chemotherapy-induced neuropathic pain by reducing neuroinflammation and oxidative stress.
- QMN patches offer a potential long-term therapeutic option for managing CINP in patients.
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