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Swept-source visible-light optical coherence tomography.

Weijia Fan, Roman Kuranov, David A Miller

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    We developed swept-source visible-light optical coherence tomography (SS-vis-OCT) by converting near-infrared lasers. This novel SS-vis-OCT imaging offers enhanced depth and improved performance for biological tissue visualization.

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    Area of Science:

    • Biomedical Optics
    • Optical Imaging
    • Laser Technology

    Background:

    • Visible-light optical coherence tomography (vis-OCT) offers potential for high-resolution imaging.
    • Existing spectral-domain vis-OCT systems face limitations in imaging depth and signal roll-off.

    Purpose of the Study:

    • To demonstrate the feasibility of swept-source visible-light optical coherence tomography (SS-vis-OCT).
    • To improve imaging depth and signal roll-off compared to spectral-domain vis-OCT.

    Main Methods:

    • Utilized a fanout periodically poled lithium niobate (PPLN) crystal for second-harmonic generation (SHG).
    • Converted a near-infrared swept-source (NIR-SS) laser to a visible-light SS laser, amplified by booster optical amplifiers (BOAs) to achieve 580 µW power.
    • Validated performance using a 3D-printed pyramid phantom with measurements cross-validated by scanning electron microscopy (SEM).

    Main Results:

    • Achieved a maximum axial resolution of 7.3 µm in air (5.4 µm in tissue).
    • Reached an imaging depth of 5 mm in air (3.7 mm in tissue).
    • Demonstrated a 2.2-fold increase in imaging depth and a 2.8-fold improvement in roll-off compared to spectral-domain vis-OCT.

    Conclusions:

    • Swept-source visible-light OCT (SS-vis-OCT) is feasible and offers significant advantages over existing methods.
    • The developed SS-vis-OCT system provides enhanced imaging depth and improved performance for high-resolution visualization.
    • This technology holds promise for advanced biomedical imaging applications.