Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.0K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.0K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

10.8K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
10.8K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Conservation of Protein Domains02:26

Conservation of Protein Domains

3.1K
3.1K
Protein Families02:47

Protein Families

15.2K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
15.2K
Convergent Evolution01:54

Convergent Evolution

27.4K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
27.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why grain growth is not curvature flow.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Grain boundaries are Brownian ratchets.

Science (New York, N.Y.)·2024
Same author

Nonequilibrium hyperuniform states in active turbulence.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Disconnection flow-mediated grain rotation.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Scalable Disordered Hyperuniform Architectures <i>via</i> Nanoimprint Lithography of Metal Oxides.

ACS applied materials & interfaces·2021
Same author

Templated dewetting of single-crystal sub-millimeter-long nanowires and on-chip silicon circuits.

Nature communications·2019

Related Experiment Video

Updated: May 30, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

408.7K

Inferring traits of hyperuniformity from local structures via persistent homology.

Abel H G Milor1, Marco Salvalaglio1,2

  • 1Institute of Scientific Computing, TU Dresden, 01062 Dresden, Germany.

Journal of Physics. Condensed Matter : an Institute of Physics Journal
|January 31, 2025
PubMed
Summary

This study reveals that local structural information, analyzed using persistent homology and machine learning, can accurately detect and quantify hyperuniformity (HU) in finite point patterns. This enables the inverse design of patterns with specific topological and global properties.

Keywords:
Wasserstein distancecorrelated disorderhyperuniformitymachine learningpersistent homologypoint patterns

More Related Videos

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
07:54

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

18.6K
Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps
08:59

Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps

Published on: October 28, 2018

7.0K

Related Experiment Videos

Last Updated: May 30, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

408.7K
Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
07:54

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

18.6K
Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps
08:59

Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps

Published on: October 28, 2018

7.0K

Area of Science:

  • Physics
  • Materials Science
  • Data Science

Background:

  • Hyperuniformity (HU) describes suppressed large-scale density fluctuations, observed in both ordered and disordered systems.
  • HU is crucial for understanding pattern formation and phenomena like light interaction and transport.
  • Finite-sized disordered systems present challenges for characterizing global HU properties.

Purpose of the Study:

  • To explore the inverse relationship between hyperuniformity and local structural properties in point patterns.
  • To assess the use of persistent homology and machine learning for detecting HU in finite systems.
  • To enable the reconstruction of global HU parameters from local topological data.

Main Methods:

  • Utilizing persistent homology to analyze local arrangements within point patterns.
  • Training standard machine learning algorithms on persistence diagrams.
  • Comparing persistence diagrams of targeted patterns with reference HU patterns.

Main Results:

  • Machine learning accurately detects hyperuniformity in periodic point patterns using topological data.
  • Local structural information effectively characterizes finite arrangements analogous to HU patterns.
  • Global hyperuniformity parameters can be reconstructed from local topological features.

Conclusions:

  • Persistent homology and machine learning provide powerful tools for analyzing hyperuniformity in finite systems.
  • Local structural analysis is key to understanding and characterizing global hyperuniform properties.
  • This work lays the foundation for inverse design of hyperuniform patterns with desired topological characteristics.