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Bioinks for engineering gradient-based osteochondral and meniscal tissue substitutes: a review.

Mahdieh Heydarigoojani1, Maryam Farokhi2, Sara Simorgh3,4

  • 1Department of Mechanical Engineering, University of Ottawa, Ottawa, ON, Canada.

Biofabrication
|January 31, 2025
PubMed
Summary

This review explores 3D bioprinting for creating gradient tissue substitutes, mimicking natural anisotropic tissues like osteochondral and meniscal tissues for improved regeneration.

Keywords:
bioinksgradient tissuemeniscal tissue substituteosteochondral tissue substitute

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Gradient tissues exhibit anisotropic properties crucial for function.
  • Osteochondral and meniscal tissues display property gradients vital for their roles.
  • Replicating these gradients in tissue substitutes is key for injury repair.

Purpose of the Study:

  • To review gradient properties in osteochondral and meniscal tissues.
  • To explore 3D bioprinting strategies for gradient tissue engineering.
  • To discuss challenges and future directions in gradient tissue substitute development.

Main Methods:

  • Detailed analysis of gradient characteristics in native tissues.
  • Review of bioink components and 3D bioprinting techniques.
  • Examination of recent advancements in gradient osteochondral and meniscal tissue substitutes.

Main Results:

  • 3D bioprinting enables recreation of tissue-specific property gradients.
  • Zone-specific bioinks and layer-by-layer deposition are key fabrication strategies.
  • Significant progress has been made in engineering gradient tissue substitutes.

Conclusions:

  • Advanced manufacturing, particularly 3D bioprinting, offers promising solutions for gradient tissue engineering.
  • Further research is needed to overcome current challenges in developing functional gradient tissue substitutes.
  • This field holds potential for broader applications in engineering complex, anisotropic tissues.