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Predictive value of left atrial strain for left ventricular reverse remodeling in dilated cardiomyopathy

Qimin Fang1, Ao Kan1, Shuhao Li1

  • 1Department of Radiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiang Xi, China.

International Journal of Cardiology
|January 31, 2025
PubMed

Insights

Left atrial strain parameters, including left atrial conduit strain (LACS), can help predict left ventricular reverse remodeling (LVRR) in dilated cardiomyopathy (DCM) patients. This aids in tailoring treatment for better outcomes.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Dilated cardiomyopathy (DCM) poses challenges in predicting left ventricular reverse remodeling (LVRR).
  • Early LVRR prediction is crucial for optimizing treatment strategies in DCM patients.

Purpose of the Study:

  • To evaluate the predictive value of left atrium (LA) strain parameters for LVRR in DCM patients.
  • To identify key imaging and clinical factors for LVRR prediction.

Main Methods:

  • Retrospective analysis of clinical and CMR imaging data from 116 DCM patients (Jan 2018-Jan 2023).
  • LA strain parameters, including left atrial conduit strain (LACS), were derived from CMR images.
  • Logistic regression analysis was employed to identify independent predictors of LVRR.

Main Results:

  • LVRR occurred in 69 patients within one year.
  • Left ventricular end-diastolic volume index (LVEDVi), LACS, and late gadolinium enhancement extent (LGE%) were identified as independent predictors of LVRR.
  • A predictive model combining NYHA class, LVEDVi, LGE%, and LACS demonstrated strong performance (AUC = 0.807).

Conclusions:

  • LVEDVi, LACS, and LGE% are significant independent predictors of 1-year LVRR in DCM.
  • Combining clinical and imaging parameters, including LACS, enhances LVRR prediction accuracy.
Abstract

Keywords:
Cardiac magnetic resonanceDilated cardiomyopathyLeft atrial stainLeft ventricular reverse remodelingPrognosis

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