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Updated: Jul 13, 2026
Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver
Published on: June 16, 2023
Peak-postoperative Serum Transaminases Correlate With Post-hepatectomy Liver Failure and Inflow Occlusion After
Hajime Kamiya1, Taisuke Imamura2, Hisashi Ikoma1
1Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Background/Aim:
Peak-postoperative serum transaminases (PST) may indicate hepatocellular damage caused by liver resection and ischemia-reperfusion injuries induced by inflow occlusion. However, the potential of PST to predict postoperative outcomes and its correlation with the duration of inflow occlusion remains controversial. Moreover, there have been no reports regarding PST after laparoscopic liver resection (LLR). This study aimed to evaluate the efficacy of PST after LLR and the correlation between PST and the duration of inflow occlusion.
Patients And Methods:
A total of 313 consecutive patients who underwent LLR between 2012 and 2023 were included in this study.
Results:
The area under the receiver-operating characteristic curve values of PST-AST and PST-ALT for predicting post-hepatectomy liver failure (PHLF) was 0.801 and 0.790, respectively. We defined PST-AST or PST-ALT ≥1,000 U/l as an exceptionally high PST. Multivariate analysis revealed that an exceptionally high PST was an independent risk factor for PHLF [p<0.001; odds ratio (OR)=25.50 (95% CI=5.35-121.00)]. PST-AST and PST-ALT correlated with the duration of inflow occlusion (Spearman's ϱ=0.5306 and 0.5632, p<0.001).
Conclusion:
Exceptionally high PST (≥1,000 U/l) is an independent risk factor for PHLF. The duration of inflow occlusion correlates with PST following LLR.
