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Updated: May 29, 2025

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
Molecular Classification of Urothelial Carcinoma
Jie-Fu Chen1, Hikmat Al-Ahmadie1
1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center.
None:
Urothelial carcinoma exhibits a wide spectrum of morphologic and molecular heterogeneity. Advances in molecular testing have improved our understanding of the molecular biology of urothelial carcinoma, including recurrent genomic alterations and transcriptomic features, leading to the development of molecular classification schemes with potential therapeutic implications. This review summarizes the molecular characteristics of urothelial carcinoma, focusing on genomic and transcriptomic features, updates on variant histology, and novel biomarkers that may guide contemporary and future clinical management.
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