CT demonstration of cardiophrenic angle lymphadenopathy in Hodgkin disease

Eleven patients with Hodgkin disease involving the cardiophrenic angle lymph nodes are described. Four were discovered at the time of initial staging, and the remainder represented a major site of relapse after therapy. Regression of adenopathy after chemotherapy was documented in six patients; surgical excision (three), biopsy (one) and postmortem examination confirmed the presence of recurrent disease in the remaining cases. Enlargement of cardiophrenic angle nodes was frequently overlooked on conventional chest radiography, but a rather typical appearance is readily identifiable on CT.