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Updated: May 29, 2025

A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Small intestine changes, large intestine problems
Deepanshu Singla1, Abigail E Rose1, Wenhan Zhu1
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Abstract:
Enteric pathogens must overcome host microbiota-mediated colonization resistance to colonize the gut. Radlinski et al. discovered that Salmonella invasion of the small intestine leads to amino acid malabsorption. This increases amino acid availability in the large intestine, fueling Salmonella colonization through amino acid decarboxylation and counteracting SCFA-mediated cytoplasmic acidification.
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