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Vaccine microarray patch self-administration: A preliminary study in adults 50 years of age and over
C Davies1, B Baker2, M N Berger3
1Speciality of Child and Adolescent Health, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Sydney Infectious Diseases Institute, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Vaccine
|January 31, 2025
Summary
The High-Density Microarray Patch (HD-MAP) is safe and effective for vaccinating adults over 50. Participants preferred this convenient self-administration method for potential future vaccine delivery.
Area of Science:
- Vaccinology
- Dermatology
- Biomedical Engineering
Background:
- Assessing the safety, performance, acceptability, and usability of the High-Density Microarray Patch (HD-MAP) for vaccination in adults aged 50 and over.
- Investigating a novel vaccine delivery system for an aging population.
Purpose of the Study:
- To evaluate the HD-MAP as a potential vaccination method for individuals aged 50 years and above.
- To compare trained user administration versus self-administration of the HD-MAP.
- To assess participant feedback on the HD-MAP's ease of use, convenience, and acceptance.
Main Methods:
- A single-centre, open-label, single-arm study involving healthy adults aged 50+.
- HD-MAPs (vaccine-free) were applied by a trained user and self-administered to the volar forearm and upper arm.
- Skin response was compared between application sites and administration methods; acceptability and usability were assessed via surveys and interviews.
Main Results:
- The HD-MAP was well-tolerated with no serious adverse events.
- Skin response (transepidermal water loss) was comparable between trained user and self-administration.
- Participants found the applicator easy to use, preferred HD-MAP vaccination over intramuscular injection (if efficacy is proven), and highly accepted self-administration for convenience.
Conclusions:
- HD-MAPs are safe and effective for adults 50+, with performance consistent regardless of administrator.
- Participants favored the HD-MAP for its ease of use and convenience in self-administration.
- This vaccine delivery technology shows significant promise for future implementation in this demographic.
Keywords:
AcceptabilityAdultsHigh-density microarray patchMicroarray patchOlder adultsSafetySelfadministrationUsabilityVaccinationVaccine
