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Molecular mechanisms of temporomandibular joint degeneration in large animal models
J L G C Monteiro1, Y M Sillmann1, T M Kambakhsh2
1Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.
Abstract:
The aim of this scoping review was to summarize the results of large animal models investigating the molecular mechanisms of temporomandibular joint degenerative diseases (TMJ-DD). A search of the PubMed/MEDLINE, Embase, and Cochrane Library databases was performed, up to April 2024, using specific terms related to large animals and TMJ-DD. Identified studies had to be published in English. Two reviewers independently selected articles based on the inclusion criteria, with disagreements resolved by a senior author. Compliance with the ARRIVE guidelines was assessed for all studies, evaluating adherence to reporting standards across 21 checklist items. The search yielded 649 non-duplicate articles, of which 616 were excluded after title and abstract screening . The remaining 33 articles and one additional study identified in a hand-search underwent full-text review . Ultimately, seven studies were included, with three focusing on sheep, two on horses, and two on pigs. This review summarizes the biological markers involved in TMJ-DD and discusses their relevance in developing targeted and minimally invasive strategies to prevent the initiation and/or progression of joint disease.
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