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Pooled screening for endogenous HHV-6 in subjects with coronary artery disease

Rie Koide1,2, Yoshie Nakashima3, Shohei Kojima1,2

  • 1Genome Immunobiology RIKEN Hakubi Research Team, RIKEN Cluster for Pioneering Research and RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Virus Genes
|January 31, 2025
PubMed

Insights

Endogenous human herpesvirus 6 (eHHV-6) integration was screened in myocardial infarction (MI) patients. This study found eHHV-6 in 0.57% of MI patients, suggesting a potential link to coronary artery disease.

Area of Science:

  • Genetics
  • Virology
  • Cardiology

Background:

  • Endogenous human herpesvirus 6 (eHHV-6) is found in approximately 1% of the human population.
  • eHHV-6 has been anecdotally linked to angina pectoris, a condition often indicative of coronary artery disease.

Purpose of the Study:

  • To investigate the association between endogenous human herpesvirus 6 (eHHV-6) and myocardial infarction (MI).
  • To determine the prevalence of eHHV-6 in a large cohort of MI patients.

Main Methods:

  • Genomic DNA samples from 2976 MI patients were screened for eHHV-6 using multiplex quantitative PCR (qPCR).
  • Identified eHHV-6 variants included eHHV-6A, eHHV-6B, and a solo-DR form of eHHV-6B.

Main Results:

  • eHHV-6 was detected in 17 individuals (0.57%) within the MI patient cohort.
  • Specific variants identified were 6 eHHV-6A, 10 eHHV-6B, and 1 solo-DR eHHV-6B.
  • A non-statistically significant trend towards higher total cholesterol was observed in eHHV-6 positive individuals.

Conclusions:

  • This large-scale screening confirms the presence of eHHV-6 in MI patients.
  • The findings support further research into the role of eHHV-6 in cardiovascular diseases and other complex traits.

Keywords:
Coronary artery diseaseEndogenous human herpesvirus 6Myocardial infarctionPooled screening

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