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Published on: February 9, 2019
Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects
Zhe Cheng1, Huichao Huang2,3, Meilong Yin1
1Department of Emergency, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Abstract:
Liposomes and lipid nanoparticles are common lipid-based drug delivery systems and play important roles in cancer treatment and vaccine manufacture. Although significant progress has been made with these lipid-based nanocarriers in recent years, efficient clinical translation of active targeted liposomal nanocarriers remains extremely challenging. In this review, we focus on targeted liposomes, stimuli-responsive strategy and combined therapy in cancer treatment. We also summarize advances of liposome and lipid nanoparticle applications in nucleic acid delivery and tumor vaccination. In addition, we discuss limitations and challenges in the clinical translation of these lipid nanomaterials and make recommendations for the future research in cancer therapy.
Insights
Liposomes and lipid nanoparticles show promise in cancer therapy and vaccines. However, clinical translation of targeted liposomal nanocarriers faces significant challenges, requiring further research for improved cancer treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Liposomes and lipid nanoparticles are established lipid-based nanocarriers.
- These nanocarriers are crucial in cancer treatment and vaccine development.
- Clinical translation of targeted liposomal nanocarriers is challenging.
Purpose of the Study:
- Review advances in targeted liposomes, stimuli-responsive strategies, and combined therapies for cancer.
- Summarize applications of liposomes and lipid nanoparticles in nucleic acid delivery and tumor vaccination.
- Discuss challenges and future directions for lipid nanomaterials in cancer therapy.
Main Methods:
- Literature review of recent advancements in lipid-based nanocarriers.
- Analysis of targeted liposomes, stimuli-responsive systems, and combination therapies.
- Evaluation of applications in nucleic acid delivery and cancer vaccines.
Main Results:
- Significant progress in lipid-based nanocarriers for cancer and vaccines.
- Targeted liposomes, stimuli-responsive strategies, and combined therapies show potential.
- Lipid nanoparticles are advancing nucleic acid delivery and tumor vaccination.
Conclusions:
- Clinical translation of active targeted liposomal nanocarriers remains a significant hurdle.
- Further research is needed to overcome challenges in lipid nanomaterial clinical translation.
- Future directions include optimizing targeted delivery, stimuli-responsiveness, and combination strategies for enhanced cancer therapy.
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